My thoughts on carrying a weapon on your adventures:
When travelling with a firearm you need to do your research on gun laws for where you are travelling like where your concealed permit may have reciprocity if you are using one. Some states require that you notify a law enforcement officer that you are carrying when you are stopped, others do not. Having a firearm with you may restrict you from entering some places such as dams and other federal places. Travelling across an international border will take a lot of paperwork in advance and will limit your choice of weapon. Keeping a firearm locked away in your vehicle when you are not used to having one can make it easy to 'forget' it's there, and you accidently take it where you should not.
Many places you can carry a handgun 'open carry' in a visible holster without a permit, but doing so can and will get you some negative attention from others, either general public, or even members of your own group that you are travelling with. Guns in plain sight just make some people nervous. If you have a permit and carry concealed, make sure it stays that way as exposing a concealed firearm (unless you need to protect yourself) can get you cited. be discrete when moving your weapon from concealed to storage in your vehicle. It takes a lot of practice and time to comfortably and safely carry a firearm on your person, you need to make sure you are comfortable and consistent with the carry, draw and use from whichever holster you choose before running around with it loaded so you do not put a round in your foot or somewhere else it should not be. As many other have mentioned here - TRAINING and PRACTICE are key
If you select a long gun for your vehicle there are locking, quick access mounts are available to secure it in your rig, many are set up for particular vehicles and can keep the weapon out of site and secure, just make sure the ammo is removed and stored somewhere else while traveling. Also it won't do you much good if your in the roof top tent and the gun is locked in the rig...
We carry concealed most often as the gun is always where we need it and under our control, If we are out and about in a high bear or cougar area we may open carry during that time to reduce the access time (also carry bear spray). We do have a secure lock box in the rig to secure our weapons when we go into a building where guns are not allowed, and stash them there any time we decide to have adult beverages, if we do not deem the campsite safe enough from 2 or 4 legged threats to not have a firearm, then it's not safe enough to be drinking anyway... If its a 2 legged issue them we should not be there anyway.. and time to move. The type of people that cause the most trouble do not seem to get far into the woods from towns or other populated areas, so going a few miles deeper into the backcountry will greatly reduce the chance of an issue.
In all things, situational awareness is key, and far more effective then any gun. If something does not feel right, then listen to your hebe-jebes and go somewhere else. Do not get in a habit of carrying a weapon change that, it's just another tool to keep you prepared and you should be trained and practiced in its use. I had a firearms instructor tell me that every bullet has a tiny lawyer attached to it, so think about where its going and what is beyond your target before dispatching it.