I ran some on my Samurai and had no issues. I almost bought some for my new 2016 4runner, but instead decided on some P-rated ATs to save 25lbs per corner.
My 4Runner came with these crazy dealer-installed 20x10s with 33x12.5 Mud Claws. I definitely second the need for a good balancing, because they certainly had a shimmy at about 50mph. I won't blame the tires just yet, because honestly I am 100% confident in the quality of the tire install.
I am still debating, though, on a set for the next go around. I probably will whenever I get a flat. Turns out, my wife didn't actually mind the tire noise, and as I get more into the idea of adventuring around along I of course I like the idea of a tougher tire with more traction. Id have no issues getting a set of 33x12.5s from them.