Sure run them. Understand what your doing though.
Wheel spacers are not going to stress your hubs anymore than offset on a rim. Realistically, you shouldn't run wider than 1" over stock. That includes rim size. Anything more starts to change handling as well as wear on components.
The purists out there will tell you how they will destroy your vehicle. Those same people will use a rim with offset to move the tire out. Leverage is leverage. Both cause the same wear and stress because they bolt to the same spot on your suspension. It gets down to what your doing, how much your moving the tire and how much your tire/rim weighs. I've seen guys stack two 2.5" spacers, run 38" tires and run in the rocks. The wheel bearings weren't happy but that just meant more maintenance.
The proper way to move the tire out is widen the suspension. Which is what you would do for racing. Other than that, just don't go crazy. Bigger tires, dirt driving, extra weight from bumpers, winchs....all stress your suspension. You should be checking your bearings and ball joints regularly if you drive in dirt anyway.