It's not difficult. To understand what you need to do, look at the seals on your car door. On your drawer, you want to install a
weather strip along the inside. I prefer the hollow bulb type, not solid. The next trick is tension. The door has to crush the weather strip snugly. Too tight and it pinches too loose and it leaks. This is where you need to be able to adjust the latch. When I adjust door seals, I close a dollar bill in the strip. When I pull the bill out, it should have a little bit of drag. If the drawer is sitting under water for a length of time, theres not alot your going to do. Done correctly it will withstand up to a direct pressure wash.
Considering your building one, you can design the weatherstrip into it. On mine, I would have to remake the drawer to give me a flat surface for the seal and what it sits against.