ARB 50 all the way. I used a variety of cooler set-ups for decades and now that I have a 12v fridge, I can't imagine using anything else, even for short weekend jaunts. I keep my fridge in my vehicle, not trailer, so I always have food and drinks with me. Fits perfectly into my kitchen work flow when camping, too.
Much much easier to use, super easy to keep powered, and more than pays for itself in the long run. Can't vouch for all the other 12v fridge/freezers, but the ARB has a 12v plug and outlet you can get that screw together, so no chance of it vibrating out on the trail. Even though I have deep cycles in my trailer, I regularly run my 12v fridge just from the starting battery system on my van.
** One thing a lot of people don't consider when thinking about getting a 12v fridge is that the ARB has (and I suspect most other 12v fridges have) an integrated battery protection system that senses when your battery is getting low, so reduces power to the fridge. Makes it much easier to use your vehicle battery and not get an auxiliary battery right away if you don't want. I've never had a problem yet, with over 10,000 miles of travel on the fridge, of it draining my battery or of the fridge temp getting too warm. I forgot it had the battery protection at first and would unplug it after it got to temp.
Only pulls around 1.2 amp when it is running, though it is so efficient that it really doesn't have to run constantly to stay at temp.
** Another thing SO many users overlook with 12v fridges is allowing your unit to have enough space around it for the vents to work properly. If you stuff it into a drawer, cabinet, or storage system with tight sides, it will have to cycle more to stay at temp and will be fighting higher surrounding temps and less air circulation, eventually leading to premature wear.
.