My rig is a 2017 diesel (and my wife's is a 2016 diesel), fooling around with homemade diesel with these seems like it would be an expensive experiment. We do have B5-B20 at the pump here, though, so we do run a bio blend by default.
One thing that is taking off more, but I haven't seen around here (Illinois), is renewable diesel.
But, I guess it would help to provide details about the diesel vehicle itself when talking about running it or not. An older vehicle that doesn't have sensitive emissions equipment is totally different than a modern diesel.