Exactly, there are a lot of variables to consider. I've run E rated tires (not KO2) for many years on a heavy extended body GMC Savana van and love them for the stronger sidewalls and less puncture/wear problems in general but especially when down in the borderlands where I always seem to catch a nail or two.
My concern would be the airing down when you want and to what pressure, with the stiffer sidewalls on E-rated KO2 tires. Haven't done that with KO2's, so can't advise in that regard, but am certainly interested in other replies here. They're the tires I'm looking at for next round of rubber.
My E rated tires on the van run at 75-80 lbs pressure, and most every thread/post/article you see about airing down is meant for lighter-weight smaller vehicles, that typically run at what 35lbs full and go down to 12-15 or so when aired down?
I'd be worried about running C-rated on a heavier vehicle, personally, but I'm far from an expert.